Slow and steady

Slow and steady moves the cell

of receptor desensitization. Mutations that strengthen this interaction are more resistant to desensitization, whereas disruption of dimerization promotes desensitization. Dimer interaction takes place between domain 1 of the ligand-binding core in each subunit. When these interactions are strong, These studies also explain the mode of action of a drug that promotes AMPA activation, cyclothiazi...

Slow but steady wins the drug race

Without the SNF-6 acetylcholine transporter (bottom) mutant muscles fall apart. K im /M ac m ill an they are mutant for various members of the dystrophinglycoprotein complex (DGC), which links intracellular actin to extracellular laminin. But now, Hongkyun Kim, Steven McIntire (University of California, San Francisco, CA), and colleagues suggest that loss of the DGC results in loss of an associ...

Travellers' diarrhoea: slow but steady progress.

Pediatric vesicoureteral reflux: Slow but steady steps

Vesicoureteral reflux (VUR) is a common urological anomaly that is found in 1% of children. VUR can cause recurrent febrile urinary tract infection (UTI). The recurrent infections can result in renal scarring, which can lead to renal hypertension and end-stage renal disease. Thus, our therapeutic goal is to prevent febrile UTI in the short term and, in the long term, to preserve renal function ...

Slow Steady-Shear of Plastic Bead Rafts

Experimental measurements of the response of a two dimensional system of plastic beads subjected to steady shear are reported. The beads float at the surface of a fluid substrate and are subjected to a slow, steadyshear in a Couette geometry. The flow consists of irregular intervals of solid-like, jammed behavior, followed by stress relaxations. We report on statistics that characterize the str...